How Long Will Vaccinations Protect Against COVID-19?
Moderna vaccine can provide immunity for at least 3 months. At the heart of this news is an article published yesterday in the highly respected medical scientific journal New England Journal of Medicine (NEJM). The original article is here: https://www.nejm.org/doi/full/10.1056/NEJMc2032195.
There is some overkill in the presentation of this news to the media. The fact is that the article presents only data on the dynamics of antibody titers. But it is not yet known whether these antibodies are reliable indicators of protection. And patronage can be different.
The article describes how titers of binding and neutralizing antibodies change within 119 days after the first immunization (90 days after the second). Binding antibodies are those that are known to bind specifically to protein S, and no more. In this work, binding antibodies against RBD (receptor binding domain) were determined. This region of the S protein is directly involved in the “mooring” of the virus to the receptor. It contains most, although not all of the epitopes of protein S, the binding of antibodies to which leads to the neutralization of the virus. Neutralizing antibodies are those that, as a result of binding to the virus, it loses its infectivity in vitro.