Seasonal viral infections
Artificial climatic conditions surrounded the modern person at home, at work, in school and in transport. However, the absence of long-term contacts of the body with the natural environment has reduced the ability to adapt to abrupt weather changes in the off-season. The maladjustment, in turn, led to the general incidence of seasonal colds, which is not typical for animals living in natural conditions. This is my story about how the contact of the body with cold triggers the ancient reflex of protection against hypothermia, and why for a modern person it turns into a regular cold.
You will also find out with the help of which biohacks you can hack this mechanism and prevent seasonal illness.
Evolutionary pathophysiology of the common cold
Sharp cooling of a vast body surface causes reflex narrowing of the skin capillaries, which leads to redistribution of up to a liter of blood into the body. This ancient reflex is relevant for all warm-blooded animals, especially those living in northern latitudes. For example, when an animal enters cold water, this reflex reduces heat loss and prevents general hypothermia of the body in order to maintain a high metabolism in the central nervous system and muscles, which is necessary for salvation.
Of course, in a modern city, the risk of falling under the ice is negligible, but a person who is pampered by climate comfort increases sensitivity to the effects of cold, and a breath of cold wind is enough to falsely trigger an ancient reflex. In addition, in a person who is not adapted to the cold climate, the cold spasm of the capillaries is not replaced by their expansion until the ambient temperature rises to a comfortable one. The characteristic features of the described condition are chilliness and frostiness, which is well known to many people. Everything would be fine, but it is in this state that the upper respiratory tract is vulnerable to infection and the development of a cold. Why is this happening?
The pathogenesis of the common cold
Heat exchange between the body and the environment occurs not only through the skin, but also with respiration, therefore, when exposed to cold in order to reduce heat transfer, the cold spasm of capillaries is also realized on the mucous membranes of the upper respiratory tract. As a result of a slowdown in blood microcycling in the mucous membranes of the mouth and nose, the production of lysozyme, nucleases, antibodies, interferon and other factors of local immunity decreases. The outflow of blood, in turn, further reduces the temperature of the mucous membranes, which worsens the interaction of the receptors of lymphocytes and antibodies with the antigens of the pathogen.Поділитися цим: